TWN Info Service on Health Issues (Aug18/03)
3 August 2018
Third World Network

India: Poor urban women have higher risk for CA-AMR with ESBL

Dear friends and colleagues,

In a study to identify risk factors for community-acquired antimicrobial resistance (CA-AMR) with extended-spectrum β-lactamase (ESBL) producing organisms among urban-dwelling women in India, data of women carrying a pregnancy to full term for the first time, in a public hospital in Hyderabad, India were analysed.

The researchers found that seven percent of 1,836 women had bacteriuria; 48 percent of isolates were ESBL-producing organisms. Women in the bottom 50th percentile of income distribution were more likely to have bacteriuria, and significantly more likely to have bacteriuria with ESBL-producing organisms.

‘These data point to an alarming rate of community-acquired AMR in extended spectrum β-lactamase (ESBL) producing organisms… in Hyderabad, India. Such trends are of international concern given the possibility of AMR pathogens and genetic elements to spread across political and geographic boundaries,’ wrote the authors of the study.

They said that the most likely explanation for the findings ‘appears to be that the poor are exposed to an environmental source of antimicrobial drugs that is placing them at higher risk for CA-AMR than their wealthier peers, resulting in the CA-AMR wealth gradient that we observed’.

‘In Hyderabad, other researchers have noted levels of many antimicrobial drugs in wastewater treatment plants and treatment plant effluent, including ciprofloxacin, that are several-fold higher than maximal therapeutic plasma levels,’ they added.

The study was published in Emerging Infectious Diseases journal Vol 24 No 8 August 2018.

With best wishes,

Third World Network