ABOUT THE BOOK
The integration of foreign DNA into an established genome, through genetic engineering, may have unanticipated side-effects in the recipient organism. Despite this, genetically modified organisms (GMOs) are often claimed to be ‘substantially equivalent’ to their unmodified counterparts. This paper examines whether this claim is justified, by looking at whether a GMO, compared to its unmodified counterpart, has experienced changes in the interacting regulatory parts, its ‘interactome’: the genome, epigenome, transcriptome, proteome and metabolome, which work as overlapping layers of information involved in cellular function. Examples are given, from a precautionary point of view, of the changes that may occur in modified genomes and the consequences they may have.
ABOUT THE AUTHOR
Kaare M Nielsen is a Professor of Pharmaceutical Microbiology at
the Department of Pharmacy, the
David Quist is a senior scientist at GenØk-Centre for Biosafety
Terje Traavik is the author of more than 200 scientific articles
and book chapters. He was Professor of Virology at the
Chapter 1. Introduction
Chapter 2. Lack of Precision in Recombinant DNA Techniques
2.1 The ‘-omes’ and the ‘-omics’
Chapter 3. Changes in the Genome
3.1 Observations from studies of genetically modified (GM) plants
3.2 Why do DNA rearrangements occur?
Chapter 4. Changes in the transcriptome
4.1 Example of new transcripts originating from a plant transgene
4.2 Examples of the activity of the 35S CalMV plant promoter in mammalian cells
4.3 Example of upregulation of an endogenous gene under the influence
of a transgene promoter
4.4 Does ‘transvection’ occur during transgenesis in mammalian cells?
Chapter 5. Changes in the Proteome
5.1 An a-amylase inhibitor-1 gene transferred from common bean to pea
5.2 Production of recombinant protein in milk
Chapter 6. Changes in the Metabolome
Chapter 7. Changes in the Epigenome
Chapter 8. Changes in the Interactome
Chapter 9. Concluding Remarks
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